Citation Information :
Kammili J, Raghuwanshi N, Arshad M. Evaluating the Effects of Vitamin D on Chronic Rhinosinusitis without Nasal Polyposis. Clin Rhinol An Int J 2024; 15 (2):63-67.
Aim: Chronic rhinosinusitis (CRS) poses a substantial challenge for ENT surgeons, affecting a significant portion of the global population. This study aims to enhance our understanding of the interplay between vitamin D and CRS, offering a foundation for future research and contributing to the development of personalized treatment strategies for individuals grappling with this challenging chronic condition.
Materials and methods: This prospective study investigates the potential therapeutic effects of vitamin D supplementation on CRS. We studied the effects of vitamin D on 50 patients with CRS and vitamin D deficiency, utilizing stringent inclusion and exclusion criteria. Participants were randomly assigned to either a test group receiving Vitamin D3 supplementation or a control group with a placebo. The comprehensive evaluation involved three assessments: levels of vitamin D, symptom severity evaluation using the sinonasal outcome test-22 (SNOT-22) questionnaire, and sinus computed tomography (CT) scans employing the Lund-Mackay scale.
Results: The findings of this study suggest that oral vitamin D supplementation, as part of a comprehensive treatment regimen, may be beneficial in managing CRS in individuals with vitamin D deficiency.
Conclusion: The improvements observed in symptomatology and sinus health underscore the potential role of vitamin D in the management of this condition. Further research with larger sample sizes and longer follow-up periods is warranted to validate these findings and explore the long-term effects of vitamin D supplementation.
Clinical significance: This study's clinical significance lies in its potential to enhance CRS management through vitamin D supplementation. Demonstrating the benefits of addressing vitamin D deficiency in CRS patients, it introduces a novel, cost-effective treatment avenue. Implementing vitamin D assessment and supplementation in CRS care could lead to improved symptom control and enhanced quality of life (QoL). Overall, the study's findings offer valuable insights for improving CRS management strategies globally.
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