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VOLUME 9 , ISSUE 2 ( May-August, 2016 ) > List of Articles


Mucociliary Function: Its Variations with Disease

Satish C Kumar, AP Preetham, Musarrat Feshan

Keywords : Chronic rhinosinusitis,Mucociliary clearance,Sacchain,Smokers

Citation Information : Kumar SC, Preetham A, Feshan M. Mucociliary Function: Its Variations with Disease. Clin Rhinol An Int J 2016; 9 (2):68-73.

DOI: 10.5005/jp-journals-10013-1271

Published Online: 01-08-2016

Copyright Statement:  Copyright © 2016; The Author(s).



This study compares the nasal mucociliary clearance time of patients with chronic sinusitis (pre- and postoperatively) and smokers, with controls, attending the ear, nose, and throat outpatient department at Southern Railway Headquarters Hospital, Perambur, Chennai.

Materials and methods

Saccharin granule was used to study mucociliary clearance as it is safe, easy, fast, and reliable. A total of 32 patients in each group were studied. In chronic rhinosinusitis patients, the test was done preoperatively and 4 weeks postoperatively.


The average mucociliary clearance time pre- and post-operatively in chronic rhinosinusitis patients was 29.54 ± 28.68 and 12.17 ± 5.84 respectively. Cigarette smokers had a longer mucociliary clearance time (27.63 ± 21.11) compared with beedi smokers (24.04 ± 24.93). Controls had the fastest mucociliary clearance rate of 9.67 ± 4.62 among the study subjects.


Surgery for chronic rhinosinusitis improves both the overall symptoms of chronic rhinosinusitis and the protective functions of the nose and paranasal sinuses. Smokers had an impaired clearance rate compared with normals. As age advances, the mucociliary clearance rate becomes slower.

How to cite this article

Vamanshankar H, Kumar SC, Preetham AP, Feshan M. Mucociliary Function: Its Variations with Disease. Clin Rhinol An Int J 2016;9(2):68-73.

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