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VOLUME 9 , ISSUE 2 ( May-August, 2016 ) > List of Articles

RESEARCH ARTICLE

Mucociliary Function: Its Variations with Disease

Satish C Kumar, AP Preetham, Musarrat Feshan

Keywords : Chronic rhinosinusitis,Mucociliary clearance,Sacchain,Smokers

Citation Information : Kumar SC, Preetham A, Feshan M. Mucociliary Function: Its Variations with Disease. Clin Rhinol An Int J 2016; 9 (2):68-73.

DOI: 10.5005/jp-journals-10013-1271

Published Online: 01-08-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

This study compares the nasal mucociliary clearance time of patients with chronic sinusitis (pre- and postoperatively) and smokers, with controls, attending the ear, nose, and throat outpatient department at Southern Railway Headquarters Hospital, Perambur, Chennai.

Materials and methods

Saccharin granule was used to study mucociliary clearance as it is safe, easy, fast, and reliable. A total of 32 patients in each group were studied. In chronic rhinosinusitis patients, the test was done preoperatively and 4 weeks postoperatively.

Results

The average mucociliary clearance time pre- and post-operatively in chronic rhinosinusitis patients was 29.54 ± 28.68 and 12.17 ± 5.84 respectively. Cigarette smokers had a longer mucociliary clearance time (27.63 ± 21.11) compared with beedi smokers (24.04 ± 24.93). Controls had the fastest mucociliary clearance rate of 9.67 ± 4.62 among the study subjects.

Conclusion

Surgery for chronic rhinosinusitis improves both the overall symptoms of chronic rhinosinusitis and the protective functions of the nose and paranasal sinuses. Smokers had an impaired clearance rate compared with normals. As age advances, the mucociliary clearance rate becomes slower.

How to cite this article

Vamanshankar H, Kumar SC, Preetham AP, Feshan M. Mucociliary Function: Its Variations with Disease. Clin Rhinol An Int J 2016;9(2):68-73.


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  1. Alterations of nasal mucociliary transport in patients with hypertrophy of the inferior turbinates, deviations of the nasal septum and chronic sinusitis. Eur Arch Otorhinolaryngol 1999;256(7):335-337.
  2. Mucociliary clearance in chronic sinusitis. Indian J Otolaryngol Head Neck Surg 1998 Jan;50(1):15-19.
  3. Evaluation of nasal mucociliary clearance after medical or surgical treatment of chronic rhinosinusitis. Eur Arch Otorhinolaryngol 2009 Sep;266(9):1423-1426.
  4. Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery. Laryngoscope 2000 Jan;110(1):117-122.
  5. Nasal mucociliary clearance in health and disease. Indian J Otolaryngol Head Neck Surg 2006 Oct;58(4):332-334.
  6. Comparison of three methods for measuring nasal mucociliary clearance in man. Acta Otolaryngol 1981 Mar-Apr;91(3-4):297-303.
  7. The effect of endoscopic sinus surgery on mucociliary clearance in patients with chronic sinusitis. Eur Arch Otorhinolaryngol 1998;255(10):511-514.
  8. Functional study of nasal mucosa in endoscopic sinus surgery and its correlation to electron microscopy of cilia. Indian J Otolaryngol Head Neck Surg 2008 Mar;60(1):1-6.
  9. Study on nasal mucous clearance in patients of perennial allergic rhinitis. Indian J Allergy Asthma Immunol 2003;17(2):89-91.
  10. Effect of cigarette smoking on nasal mucociliary clearance and ciliary beat frequency. Thorax 1986 Jul;41(7):519-523.
  11. Nasal mucociliary clearance under various conditions. Acta Otolaryngol 1983 Jul-Aug;96(1-2):167-173.
  12. Probleemdrinken: Prevalentiebepaling, beinvloedende factoren en preventiemogelijkheden: Theoretische overwegingen en onderzoek in Rotterdam. Lisse: Swets & Zeitlinger; 1983 (in Dutch).
  13. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001 Nov;108(5):S147-S334.
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