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VOLUME 4 , ISSUE 1 ( January-April, 2011 ) > List of Articles

RESEARCH ARTICLE

Effects of Aging on Nasal Mucociliary Clearance

Jyoti Yadav, Jagat Singh, Rupender K Ranga

Keywords : Mucociliary clearance, Kartagener's syndrome, Andersen's saccharin method

Citation Information : Yadav J, Singh J, Ranga RK. Effects of Aging on Nasal Mucociliary Clearance. Clin Rhinol An Int J 2011; 4 (1):1-3.

DOI: 10.5005/jp-journals-10013-1061

Published Online: 01-04-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Nasal mucociliary clearance is a primary physiological defense mechanism of upper as well as lower respiratory tract, and thus maintains the state of health of the respiratory tract. Any disturbance in number or movement of cilia and change in character or amount of mucus production leads to an altered nasal mucociliary clearance. The present study was undertaken to study the effect of aging on nasal mucociliary clearance.

Nasal mucociliary clearance time was assessed in 240 normal subjects, 120 males and 120 females, which were divided in six groups, each comprising of one decade starting from 11 to 20 years. The mean nasal mucociliary clearance time ranged 7.34 to 14.48 minutes in males and 7.36 to 15.38 minutes in females in different groups (A-F). There was no statistical difference between males and females in each group (p > 0.05). The nasal mucociliary clearance time was not found to be increased till 5th decade (p = 0.05). However, the nasal mucociliary clearance time was found to be increased in 6th and 7th decades (group E&F) significantly (p 0.001), which was more marked in group F. This may explain the increased susceptibility of elderly to sinusitis chronic bronchitis, deep lung infections and increased incidence of pneumonia.


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  1. Mucociliary clearance pattern following endoscopic sinus surgery. Laryngoscope 1995;105:1-40.
  2. Measurement of frequency of ciliary beats of human respiratory epithelium. Chest 1978;73: 627-33.
  3. Relationship of smoking history and pulmonary function tests to tracheal mucus velocity in non smokers, young smoker, ex-smoker and patients suffering from bronchitis. Am Rev Respir Dis 1978;117:205-14.
  4. Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiectasis. Thorax 1981;36:654-81.
  5. Abnormal mucociliary clearance in patients with rhinitis and its relationship to concomitant chest diseases. Br J Dis Chest 1985;79:77-82.
  6. Nasal mucous clearance in nasal and paranasal sinus disorders. Indian J Chest Dis All Sci 1988;30:176-80.
  7. Nasal clearance in monozygotic twins. Am Rev Respir Dis 1978; 110:301-05.
  8. Deposition and clearance: Unique problems in the proximal airway and oral cavity in the young and elderly. Resp Physio 2001;128:33-38.
  9. Nasal mucociliary clearance in adenotonsillar hypertrophy. Indian J Paediatr 2000; 67:651-52.
  10. Nasal mucociliary clearance in healthy children in a tropical country. Int J Paedr Otorhinolaryngol 2001;57:21-24.
  11. Cryosurgery in vasomotor rhinitis: An analysis of 156 patients. Indian J Otolaryngol 1996;42:95-98.
  12. Human nasal mucus flow rates. Indian J Otolaryngol 1977;29:174-75.
  13. The effect of cryodestruction of vidian nasal branches on nasal mucus flow in vasomotor rhinitis. Indian J Otolaryngol 1981;97:12-14.
  14. Efficiency of saccharin test for screening to detect abnormal mucociliary clearance. Br J Dis Chest 1984;78:62-65.
  15. Comparison of three method for measuring nasal mucociliary clearance in man. Acta Otolaryngol 1981;91:297-303.
  16. Study on nasal mucus clearance in patients of perennial allergic rhinitis. Indian J Allergy Asthma Immunol 2003;17:89-91.
  17. Regulation of mucociliary clearance in health and diseases. Eu Respir J 1999;13:1177-88.
  18. Oropharyngeal swallowing and aging: A review. J Commun Disord 1999;32:373-96.
  19. Predicted deposition of non hygroscopic aerosols in human lungs as a function of age. J Aerosol Med 1989;1:49-68.
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