Aim: To diagnose a rare case of lipoma in nasal septum that causes nasal obstruction. Background: Lipoma is one of the most common neoplasms in adults. Although lipoma of upper back, arms, upper thigh, buttock, and shoulders are common, lipoma of the nasal cavity, paranasal sinuses, or midface are rare due to lack of normal adipose tissue. Here, we present a 22-year-old man with lipoma on upper part of his nasal septum. Case description: A 22-year-old man presented to our hospital with the chief complaint of nasal obstruction. On physical examination, he had significant septal deviation with obvious nasal deformity. Computed tomography without contrast revealed unusual septal thickness, and subsequent magnetic resonance imaging showed an amorphous heterogeneous fat content mass. The mass was excised using submucoperichondrial approach with no complication. No recurrence was seen after 6 months, and while nasal airway opened considerably, the apparent nasal deviation was alleviated to some degree. Conclusion: Lipoma of the nasal septum is a rare presentation. While this mass may present itself as a common septal deviation, we should keep in mind rare causes of nasal obstruction other than deflected cartilages. Clinical significance: Lipoma of nasal septum is not common in the midface, and it is hard to find and rare in nasal cavity due to scarce amount of fatty tissue that presents with nasal obstruction.